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1

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

de Sa Alves, Fernando, Barreiro, Eliezer, Manssour Fraga, Carlos

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 315 KB

english, 2009

2

ChemInform Abstract: Studies on Diastereoselective Synthesis of 3-Vinyl-5-carbomethoxy-2-oxabicyclo[3.3.0]octane Derivatives Employing Palladium(II) Oxidative Cyclization.

Emerson Poley Pecanha, Carlos Alberto Manssour Fraga, Eliezer Jesus Barreiro

Journal:

Year:

1999

File:

PDF, 32 KB

1999

3

Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties

Leonardo S. Santos, Monica Costa Padilha, Francisco Radler de Aquino Neto, Alberto dos Santos Pereira, Ricardo Menegatti, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro, Marcos N. Eberlin

Journal:

Journal of Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

4

CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

Aline Guerra M. Fraga, Leandro Louback da Silva, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 652 KB

english, 2011

5

Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype

Daniela J. Conrado, Hugo Verli, Gilda Neves, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro, Stela Maris Kuze Rates, Teresa Dalla Costa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 452 KB

english, 2008

6

New optimized piperamide analogues with potent in vivo hypotensive properties

Carolina de Mattos Duarte, Hugo Verli, João Xavier de Araújo-Júnior, Isac Almeida de Medeiros, Eliezer J. Barreiro, Carlos Alberto Manssour Fraga

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 190 KB

english, 2004

7

Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats

Leandro Tasso, Gilda Neves, Ricardo Menegatti, Carlos Alberto Manssour Fraga, Eliezer Barreiro, Vera Eifler-Lima, Stela Maris Kuze Rates, Teresa Dalla Costa

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 259 KB

english, 2005

8

Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists

Emerson Poley Peçanha, Carlos Alberto Manssour Fraga, Carlos Maurício Rabello de Sant'Anna, Ana Luisa Palhares de Miranda, Eliezer Jesus Barreiro

Journal:

Year:

1998

Language:

english

File:

PDF, 1.22 MB

english, 1998

9

Proposal of a new PAF pharmacophoric map by the AM1 method

Carlos Rangel Rodrigues, Ricardo Bicca de Alencastro, , Eliezer Jesus Barreiro, Carlos Alberto Manssour Fraga

Journal:

European Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 430 KB

english, 1999

10

Drug hybridization strategies: before or after lead identification?

Fraga, Carlos Alberto Manssour

Journal:

Expert Opinion on Drug Discovery

Year:

2009

Language:

english

File:

PDF, 308 KB

english, 2009

11

Phenylpiperazine derivatives: a patent review (2006 – present)

Maia, Rodolfo do Couto, Tesch, Roberta, Fraga, Carlos Alberto Manssour

Journal:

Expert Opinion on Therapeutic Patents

Year:

2012

Language:

english

File:

PDF, 487 KB

english, 2012

12

Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels

Sharlene Lopes Pereira, Arthur Eugen Kummerle, Carlos Alberto Manssour Fraga, Eliezer Jesus Barreiro, Roberto Takashi Sudo, Gisele Zapata-Sudo

Journal:

Fundamental & Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 509 KB

english, 2012

13

Cardiovascular effects induced by N-(4'-dihydro)-piperoylthiomorpholine in normotensive rats

João Xavier Araújo-Júnior, Êurica Adélia Nogueira Ribeiro, Carlos Alberto Manssour Fraga, Lídia Moreira Lima, Eliezer Jesus Barreiro, Isac Almeida De Medeiros

Journal:

Journal of Pharmacy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 340 KB

english, 2010

14

A novel Ca²+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension

Pereira, Sharlene Lopes, Kummerle, Arthur Eugen, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer Jesus, Rocha, Nazareth de Novaes, Ferraz, Emanuelle Baptista, Nascimento, José Hamilton Matheus do, S

Journal:

European Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 552 KB

english, 2013

15

N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle

da Silva, Jaqueline Soares, Pereira, Sharlene Lopes, Maia, Rodolfo do Couto, Landgraf, Sharon Schilling, Caruso-Neves, Celso, Kümmerle, Arthur Eugen, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer

Journal:

Year:

2014

Language:

english

File:

PDF, 653 KB

english, 2014

16

Acylhydrazone derivatives: a patent review

Maia, Rodolfo do Couto, Tesch, Roberta, Fraga, Carlos Alberto Manssour

Journal:

Expert Opinion on Therapeutic Patents

Year:

2014

Language:

english

File:

PDF, 1011 KB

english, 2014

17

Crystal structures of 1-hydroxylimidazole and imidazole 1-oxide derivatives

da Silva, Ramon Borges, da Silva, Edson Ferreira, Carvalho, Samir Aquino, Fraga, Carlos Alberto Manssour, Wardell, Solange M.S.V., Wardell, James L.

Journal:

Zeitschrift für Kristallographie - Crystalline Materials

Year:

2014

Language:

english

File:

PDF, 6.15 MB

english, 2014

18

Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative

Sato, Juliana Alves Pereira, Costa, Fanny Nascimento, da Rocha, Miguel Divino, Barreiro, Eliezer J., Fraga, Carlos Alberto Manssour, Punzo, Francesco, Ferreira, Fabio Furlan

Journal:

Year:

2015

Language:

english

File:

PDF, 2.50 MB

english, 2015

19

SYNTHESIS OF NEW ISOSTERIC HETEROTRICYCLIC DERIVATIVES: PYRAZOLO[3,4-b]THIENO[3,2-e]PYRIDINE, PYRAZOLO[3,4-b]PYRROLO[3,2-e]PYRIDINE AND FURO[2,3-b]PYRAZOLO[4,3-e]PYRIDINE

de Amorim Câmara, Celso, Teixeira da Silva, Emerson, Barreiro, Eliezer Jesus, Manssour Fraga, Carlos Alberto

Journal:

Heterocyclic Communications

Year:

1999

Language:

english

File:

PDF, 927 KB

english, 1999

20

New Anti-Alzheimer Drugs from Biodiversity: The Role of the Natural Acetylcholinesterase Inhibitors

Viegas Jr., Claudio, Bolzani, Vanderlan, Barreiro, Eliezer, Manssour Fraga, Carlos

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 137 KB

english, 2005

21

LASSBio-1425, an analog of thalidomide, decreases triglyceride and increases HDL cholesterol levels by inhibition of TNF-α production

Fumian, Milla Machado, da Motta, Nadia Alice Vieira, Maia, Rodolfo, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer Jesus, Ferreira de Brito, Fernanda Carla

Journal:

International Journal of Cardiology

Year:

2016

Language:

english

File:

PDF, 569 KB

english, 2016

22

Design, Synthesis and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.

Rodrigues, Daniel Alencar, Ferreira-Silva, Guilherme, Ferreira, Ana Carolina, Fernandes, Renan, Kwee, J. K., Sant'Anna, Carlos Maurício R, Ionta, Marisa, Fraga, Carlos Alberto Manssour

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 7.62 MB

english, 2015

23

Discovery of Dual Chemotherapy Drug Candidates Designed by Molecular Hybridization

do Couto Maia, Rodolfo, Alberto Manssour Fraga, Carlos

Journal:

Current Enzyme Inhibition

Year:

2010

Language:

english

File:

PDF, 420 KB

english, 2010

24

Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates

Lima, Lidia, Manssour Fraga, Carlos, Goncalves Koatz, Vera, Barreiro, Eliezer

Journal:

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Cu rrent Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

Year:

2006

Language:

english

File:

PDF, 810 KB

english, 2006

25

New Insights for Multifactorial Disease Therapy: The Challenge of the Symbiotic Drugs

Manssour Fraga, Carlos, Barreiro, Eliezer

Journal:

Current Drug Therapy

Year:

2008

Language:

english

File:

PDF, 333 KB

english, 2008

26

Studies on Diastereoselective Synthesis of 3-Vinyl-5-carbomethoxy-2-oxabicyclo[3.3.0]octane Derivatives Employing Palladium(II) Oxidative Cyclization

Jesus Barreiro, Eliezer, Poley Peçanha, Emerson, Alberto Manssour Fraga, Carlos

Journal:

Year:

1998

Language:

english

File:

PDF, 230 KB

english, 1998

27

Antinociceptive Profile of 2,3,6-Trisubstituted Piperidine Alkaloids: 3-O-Acetyl-spectaline and Semi-synthetic Derivatives of (−)-Spectaline

Viegas Jr., Cláudio, Alexandre-Moreira, Magna Suzana, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer Jesus, Bolzani, Vanderlan da Silva, de Miranda, Ana Luísa Palhares

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2008

Language:

english

File:

PDF, 503 KB

english, 2008

28

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

da Motta, Nadia Alice Vieira, Kümmerle, Arthur Eugen, Marostica, Elisabeth, dos Santos, Caroline Fernandes, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer Jesus, de Miranda, Ana Luisa Palhares, de

Journal:

Journal of Pharmacological Sciences

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

29

ROCK inhibition with Fasudil induces beta-catenin nuclear translocation and inhibits cell migration of MDA-MB 231 human breast cancer cells

Guerra, Fabiana Sélos, Oliveira, Ramon Guerra de, Fraga, Carlos Alberto Manssour, Mermelstein, Claudia dos Santos, Fernandes, Patricia Dias

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.72 MB

english, 2017

30

Theoretical and Experimental Characterization of 1,4-N∙∙∙S σ-hole Intramolecular Interactions in Bioactive N-Acylhydrazone Derivatives

Pinheiro, Pedro de Sena Murteira, Rodrigues, Daniel Alencar, Alves, Marina Amaral, Tinoco, Luzineide, Ferreira, Glaucio Braga, Sant’Anna, Carlos, Fraga, Carlos Alberto Manssour

Journal:

New Journal of Chemistry

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

31

Rational use of antioxidants in solid oral pharmaceutical preparations

Celestino, Maísa Teodoro, Magalhães, Uiaran de Oliveira, Fraga, Aline Guerra Manssour, Carmo, Flávia Almada do, Lione, Viviane, Castro, Helena Carla, Sousa, Valeria Pereira de, Rodrigues, Carlos Range

Journal:

Brazilian Journal of Pharmaceutical Sciences

Year:

2012

File:

PDF, 784 KB

2012

32

Preparation and scale up of extended-release tablets of bromopride

Ferreira, Guilherme Neves, Silva, Marcos Giovani Rodrigues, Fraga, Aline Guerra Manssour, Silva, Luiz Cláudio Rodrigues Pereira da, Lira, Luiz Marcelo, Rodrigues, Carlos Rangel, Castro, Helena Carla,

Journal:

Brazilian Journal of Pharmaceutical Sciences

Year:

2014

File:

PDF, 950 KB

2014

33

Modeling zinc-oxygen coordination in histone deacetylase: A comparison of semiempirical methods performance

Pinheiro, Pedro de Sena Murteira, Rodrigues, Daniel Alencar, Sant'Anna, Carlos Mauricio R., Fraga, Carlos Alberto Manssour

Journal:

International Journal of Quantum Chemistry

Year:

2018

Language:

english

File:

PDF, 1.34 MB

english, 2018

34

A questão da inovação em fármacos no Brasil: proposta de criação do programa nacional de fármacos (Pronfar)

Barreiro, Eliezer J., Fraga, Carlos Alberto Manssour

Journal:

Year:

2005

File:

PDF, 1.27 MB

2005

35

Extração e purificação de fármacos anti-inflamatórios não esteroidais ciclo-oxigenase-2 seletivos

Moreira, Tailane Sant'Anna, Cid, Yara Peluso, Pierre, Maria Bernadete Riemma, Sousa, Valeria Pereira de, Kummerle, Arthur Eugen, Fraga, Carlos Alberto Manssour

Journal:

Year:

2009

File:

PDF, 903 KB

2009

36

Meet Our Section Editor

Fraga, Carlos Alberto Manssour

Journal:

Current Topics in Medicinal Chemistry

Year:

2019

File:

PDF, 124 KB

2019

37

Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal

Menegatti, Ricardo, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J., Lima, Vera Lucia Eifler, Rates, Stela Maris Kuze, Dalla Costa, Teresa

Journal:

Year:

2004

File:

PDF, 1.12 MB

2004

38

Agentes antiasmáticos modernos: antagonistas de receptores de leucotrienos cisteínicos

Lima, Lídia Moreira, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

Journal:

Year:

2002

File:

PDF, 2.71 MB

2002

39

Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química Medicinal

Menegatti, Ricardo, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J., Lima, Vera Lucia Eifler, Rates, Stela Maris Kuze, Dalla Costa, Teresa

Journal:

Year:

2004

File:

PDF, 1.12 MB

2004

40

High performance liquid chromatography method for quantification of the N-phenylpiperazine derivative LASSBio-579 in rat plasma

Conrado, Daniela J., Rates, Stela Maris Kuze, Costa, Teresa Dalla, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

Journal:

Year:

2007

Language:

english

File:

PDF, 88 KB

english, 2007

41

Novas estratégias terapêuticas para o tratamento da depressão: uma visão da química medicinal

Romeiro, Luiz Antonio Soares, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

Journal:

Year:

2003

File:

PDF, 1.46 MB

2003

42

Gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the NO/cGMP/KATP pathway

da Silva Monteiro, Carlos Eduardo, Franco, Álvaro Xavier, Sousa, Johnatan Alisson Oliveira, Matos, Victor Emanuel Araújo, de Souza, Emmanuel Prata, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

Journal:

Biochemical Pharmacology

Year:

2019

Language:

english

File:

PDF, 5.43 MB

english, 2019

43

Gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the NO/cGMP/KATP pathway

da Silva Monteiro, Carlos Eduardo, Franco, Álvaro Xavier, Sousa, Johnatan Alisson Oliveira, Matos, Victor Emanuel Araújo, de Souza, Emmanuel Prata, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

Journal:

Biochemical Pharmacology

Year:

2019

File:

PDF, 5.43 MB

2019

44

New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action

Cordeiro, Natalia de Moraes, Freitas, Rosana H.C.N., Fraga, Carlos Alberto Manssour, Fernandes, Patricia Dias

Journal:

Biomedicine & Pharmacotherapy

Year:

2020

Language:

english

File:

PDF, 1.69 MB

english, 2020

45

Therapeutic Effects of Anti-Inflammatory N-Acylhydrazones in the Resolution of Experimental Colitis

Cordeiro, NatÃ¡lia De Morais, Freitas, Rosana Helena Coimbra Nogueira, Fraga, Carlos Alberto Manssour, Fernandes, Patricia Dias

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2020

File:

PDF, 4.15 MB

2020

46

Multitarget inhibition of histone deacetylase (HDAC) and phosphatidylinositolâ3âkinase (PI3K): Current and future prospects

Fraga, Carlos Alberto Manssour, Rodrigues, Daniel A., Pinheiro, Pedro de Sena Murteira

Journal:

Year:

2020

File:

PDF, 1.43 MB

2020

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